"I'm so excited for this fight because I will know who is going to be the guy I will take the belt from," Dos Santos said on Friday. "I think Velasquez has a very good chance to be champion, but against me, it's going to be different.
I think Brock's a good fighter, too, but it doesn't matter who's going to win. When they fight against me, I will knock them out."
Dos Santos burst onto the UFC scene with an October 2008 "Knockout of the Night" win over Fabricio Werdum. Now just 26 years old, Dos Santos has worked quickly up the UFC's heavyweight ranks on the strength of six-straight impressive victories.
But while the Brazilian's octagon performances speak for themselves, Dos Santos said it's his observation of time in the gym the have him believing his time is now.
"When I started my career, I did a lot of sparring with the Nogueira brothers," Dos Santos said. "They are very good fighters, and I was starting out at that time, so they beat me a lot. Now, I feel better because with the Nogueira brothers, Anderson Silva and Lyoto Machida, they've helped me a lot, and it's important for me.
"I'm a more complete fighter than at that time, so I can do better sparring with them. Today, it's hard for them to spar with me."
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