New research kills the MRSA ‘superbug’

 

A large number of fighters have been stricken with MRSA (methi­cillin resis­tant staphy­lo­coccus aureus) including King Mo, Ken Shamrock, Kevin Randleman, among many others. The result is often a hole in your body. Don't google for images.

MRSA is not simply a plague for fighters, it is one of the leading public health threats of our time.

The potent bac­terium's resis­tance to antibi­otics has kept it one step ahead of researchers. Until now.

A ground­breaking study pub­lished Wednesday in the journal Nature by Northeastern Uni­ver­sity Pro­fessor of Biology Kim Lewis, promises a novel method to treat and elim­i­nate MRSA.

The so-??called “superbug” infects 1 mil­lion Amer­i­cans each year. A major problem with MRSA is the devel­op­ment of deep-??seated chronic infec­tions such as osteomyelitis (bone infec­tion), endo­carditis (heart infec­tion), or infec­tions of implanted med­ical devices. Once estab­lished, these infec­tions are often incur­able, even when appro­priate antibi­otics are used.

Bac­teria such as MRSA have evolved to actively resist cer­tain antibi­otics, a fact that has gen­er­ated sig­nif­i­cant interest among the sci­en­tific and med­ical com­mu­ni­ties. But Lewis, Director of Northeastern’s Antimi­cro­bial Dis­covery Center, sus­pected that a dif­ferent adap­tive func­tion of bac­teria might be the true cul­prit in making these infec­tions so devastating.

The new work rep­re­sents the cul­mi­na­tion of more than a decade of research on a spe­cial­ized class of cells pro­duced by all pathogens called per­sis­ters. According to Lewis, these cells evolved to sur­vive. “Sur­vival is their only func­tion,” he said. “They don’t do any­thing else.”

Lewis and his research team posited that if they could kill these expert sur­vivors, per­haps they could cure chronic infections—even those resis­tant to mul­tiple antibi­otics such as MRSA. Fur­ther­more, said Brian Conlon, a post­doc­toral researcher in Lewis’ lab and first author on the paper, “if you can erad­i­cate the per­sis­ters, there’s less of a chance that resis­tance will develop at all.”

Lewis found that per­sis­ters achieve their sin­gular goal by entering a dor­mant state that makes them imper­vious to tra­di­tional antibi­otics. Since these drugs work by tar­geting active cel­lular func­tions, they are use­less against dor­mant per­sis­ters, which aren’t active at all. For this reason, per­sis­ters are crit­ical to the suc­cess of chronic infec­tions and biofilms, because as soon as a treat­ment runs its course, their reawak­ening allows for the infec­tion to estab­lish itself anew.

In the recent study, Lewis’ team found that a drug called ADEP effec­tively wakes up the dor­mant cells and then ini­ti­ates a self-??destruct mech­a­nism. The approach com­pletely erad­i­cated MRSA cells in a variety of lab­o­ra­tory exper­i­ments and, impor­tantly, in a mouse model of chronic MRSA infection.

Cou­pling ADEP with a tra­di­tional antibi­otic, Conlon noted, allowed the team to com­pletely destroy the bac­te­rial pop­u­la­tion without leaving any survivors.

As with all other antibi­otics, actively growing bac­te­rial cells will likely develop resis­tance to ADEP. How­ever, Lewis said, “cells that develop ADEP resis­tance become rather wimpy.” That is, other tra­di­tional drugs such as rifampicin or line­zolid work well against ADEP-??resistant cells, pro­viding a unique cock­tail that not only kills per­sis­ters but also elim­i­nates ADEP-??resistant mutant bacteria.

While ADEP tar­gets MRSA, Lewis’ team believes sim­ilar com­pounds will be useful for treating other infec­tions as well as any other dis­ease model that can only be over­come by elim­i­nating a pop­u­la­tion of rogue cells, including can­cerous tumors. They are pur­suing sev­eral already.

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Recent Comments »

Lasko site profile image  

11/16/13 5:46 PM by Lasko

Someone needs to send this article to the Bucs. Maybe we can get half our team back next year.

KingofBJJ site profile image  

11/16/13 3:51 PM by KingofBJJ

Yes instead of cure I should have said preventative measures.  In other words your risk for a Staph infection lowers with showering after a session and spraying lysol on your mat and gym equipment after each use.

Porkchop site profile image  

11/16/13 3:04 PM by Porkchop

This just in!!!!The research team has come forward and admitted that they didn't actually cure the disease with their research....Their futile attempts at finding a cure yielded no results as science is bullshit.It turns out that they started praying that they would get a cure because they had to present results or loose their funding.The almighty God (the one and only god of course...) delivered the cure via an angel that appeared in the lab. The angel handed over the cure to the researchers and said, "See? Prayer works!"So then God (the same one that is a huge fan of cage fighting) gave them a story that they could tell the public so they didn't all lose their jobs. He also said that he "hates faggots"... It was a bit odd and it had nothing to do with the issue at hand, but the voice from above was very clear about it. In fact, he repeated it over and over out of nowhere.....At any rate... Thank God for this cure!!! Our prayers have been answered!!!Take that starving children in Africa! God loves us more!!

sadisticsoldier site profile image  

11/16/13 2:50 PM by sadisticsoldier

And if you are infected Windex does wonders.A cure for an illness is very different than preventative measures in high risk environments.

XxLiveBaitxX site profile image  

11/16/13 1:39 PM by XxLiveBaitxX

"The approach com­pletely erad­i­cated MRSA cells in a variety of lab­o­ra­tory exper­i­ments and, impor­tantly, in a mouse model of chronic MRSA infection."A huge weight of anticipation/anxiety off of the shoulders of Demetrious Johnson.

KingofBJJ site profile image  

11/16/13 1:32 PM by KingofBJJ

My understanding of Staph infection is that is caused by improper hygene.  So the best cure is always shower after each session and to clean/spray your mats, gloves weight benches with lysol after each use.

Tomas Andersson site profile image  

11/16/13 1:13 PM by Tomas Andersson

Got a bump on my forearm around 10 days ago which had me fucking worried. Especially since I sat and googled "mrsa early stages" etc. Thinking about those nasty ass boxing gloves at the gym. Or the GI I borrowed at judo. I came to the conclusion that it was probably the smelly boxing gloves. Was hoping in the back of my mind that it was just a strange pimple. But since ive never had one on my fucking forearm before that seemed strange.Turns out it is probably a pimple/cyst. Since after I popped it it has shrunk and seems to be slowly getting back to normal.Never been happier over a pimple in my life.

MagSlim site profile image  

11/16/13 1:11 PM by MagSlim

Everyone needs to read this article below. Sometimes people forget why factory farmed chicken and beef are bad -- it's because when they're fed antibiotics, they end up in you and in the water and their overuse in animals makes everyone less safe.This pervasive use of antibiotics causes MRSA (Methicillin-resistant Staphylococcus aureus) to develop such strong resistance to antibiotics.From the Washington Posthttp://www.washingtonpost.com/politics/feeding-antibiotics-to-cows-is-bad-for-humans-but-congress-wont-stop-it-new-report-says/2013/10/22/ecd2de08-3afd-11e3-a94f-b58017bfee6c_story.htmlReport: Feeding antibiotics to livestock is bad for humans, but Congress won’t stop it10/22/13By Melinda HennebergerThe farm and pharmaceutical lobbies have blocked all meaningful efforts to reduce the use of antibiotics in raising livestock in the United States, a practice that contributes to an increasingly urgent public health risk, a study released Tuesday found.Congress has killed every effort to restrict the feeding of farm animals the same antibiotics used in human medicine, the study says, even as antibiotics have grown less effective in treating infection. And regulation has gotten weaker under the Obama administration.“Our worst fears were confirmed,’’ said Bob Martin, executive director of the Johns Hopkins Center for a Livable Future, which issued the report. The Food and Drug Administration’s statistics, he said, show that as much as 80 percent of the antibiotics sold in this country are fed to food animals.The Centers for Disease Control and Prevention issued a report last month that found that 23,000 people die from antibiotic-resistant infections each year. The more a particular germ is exposed to antibiotics, the more rapidly it can develop resistance. Most scientists agree that overprescribing the drugs to humans is the predominant cause for bacteria evolving to outsmart them. Feeding the drugs widely to control and prevent disease in cows, pigs and chickens also is believed to play a role.Tuesday’s study, “Industrial Food Animal Production in America,” comes five years after a landmark report on industry practices by a Pew Charitable Trusts commission of scientists working through the Johns Hopkins Bloomberg School of Public Health. Feeding animals antibiotics for breakfast, lunch and dinner plumps them up at a terrible cost, the 2008 report said, making drugs ever-less effective and bacteria more resistant.FDA guidelines in the pipeline, Martin said, would require the industry to stop using antibiotics specifically to bulk up food animals but would continue to allow their use for disease control. But what constitutes disease control is so loosely defined, Martin said, that there would be no practical change in the use of antibiotics.“In a couple of areas, the Obama administration started off with good intentions. But when industry pushed back, even weaker rules were issued,” he said. “We saw undue influence everywhere we turned.”The report was authored by a commission that included ranchers, experts in public health and veterinary medicine, and former U.S. agriculture secretary Dan Glickman. Former Kansas governor John Carlin chaired the panel.A spokeswoman for the Animal Agriculture Alliance, Emily Meredith, said producers “tend to disagree with much of what is said in the report,” have made significant progress over the past decade and have for years been using antibiotics judiciously.The alliance, a coalition of food producers, released its own report on industry practices on Monday, defending modern farming techniques as necessary and ethical to feed a growing global population.“Food safety in this country is the best it has ever been,” Richard Raymond, a former undersecretary for food safety and inspections at the Agriculture Department, wrote in the report’s foreword.Antibiotics are part of set of biologic tools that have enabled producers to raise livestock in ways that are environmentally conscious and more humane, according to the report. “The vast majority” of antibiotics approved by the FDA for use in poultry and egg production are not used in human medicine “and therefore have little to no effect on the contribution to antibiotic resistance in humans,” the report said.The FDA’s plan to address the issue “is to phase out the use of medically important antibiotics in food animals for growth promotion and feed efficiency,” Shelly Burgess, an agency spokeswoman, said via e-mail. “FDA believes these drugs should be used only in situations where they are necessary for treating, controlling, or preventing a specifically identified disease, and only under the oversight of a veterinarian.” The Johns Hopkins report says the definition of “oversight by a veterinarian” has been changed, too, and no longer means much.The FDA also has a strategy, wrote Burgess, to “effectively phase out production uses of medically important antimicrobials” and “has worked closely with stakeholders, including the pharmaceutical industry, animal producers, veterinarians, consumer groups, and public health organizations to ensure the success of this strategy. However, FDA’s approach does not rule out future regulatory action to ensure the judicious use of these important drugs.”Rep. Louise M. Slaughter (D-N.Y.), a microbiologist by training, has been trying for 14 years to get Congress to pass the Preservation of Antibiotics for Medical Treatment Act. “No way” is the Republican-controlled House going to take up her proposed legislation, she said in an interview Monday. But it didn’t pass when Democrats were in control, either. Mary Wilson of the Harvard School of Public Health said the risk to human health is real and immediate. “We will see common infections become fatal,” just as they were before the invention of antibiotics, she said.She and other report authors said at a Tuesday news conference that the public has no idea how much the practice of modern medicine depends on antibiotics. When farmers in Denmark improved the conditions in which animals are raised, they said, they found they no longer needed to use antibiotics just to keep livestock alive until they were ready to slaughter.In this country, regulators as well as lawmakers have long given in to industry pressure, according to Slaughter. In the 1970s, the FDA announced that the two classes of antibiotics used then in both human medicine and livestock production should not be routinely fed to animals. But the agency has been backpedaling since, she said, “because the lobbying on this is fierce.”Another of the report’s authors, Michael Blackwell, a former dean of the College of Veterinary Medicine at the University of Tennessee at Knoxville, was more sympathetic to the challenges facing regulators. “Most of the people I’ve known over the years at the FDA think we have a horrible situation” in industrial animal production, he said, adding, “They live in this country, too,” and want their children eating food that is safe.Without enough real authority to force producers to do anything, Blackwell said, “what they’re doing right now is almost pleading, in their own FDA-ish way,” with industry.The only good news, the authors agreed, is that as consumers become more aware of how food is produced, they may demand changes.

Chiron site profile image  

11/16/13 12:57 PM by Chiron

War Kim Lewis & team!