I think the Komodo dragon is a worthy entry. the cat takes it out though. I think 200lb of leopard is much “bigger” than 200lb of dragon. Stronger, faster, far far better fighter, better weapons by a mile. That poison is the big equalizer though. Likely the cat wins the battle but dies due to injuries.
200lb wolverine or honey badger is a scary thought. Considering 50lb ones can at least hold their own against predators 3x their size, I think they’re the favourites here.
Bears can’t be forgotten. I would favour them over the dragon as well.
As far as hunting goes, hard to go against the cat. Ultimate predator.