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The actress has been battling symptoms of the virus since March, when she said she began experiencing fever and headache.
"Thought I'd show you what #Covid19 does to your hair," Milano tweeted along with the video. "Please take this seriously."
In the video she shows her clean detangling brush before brushing her wet hair.
"I just wanted to show you the amount of hair that is coming out of my head as a result of Covid," Milano said in the video.
Holding up a large clump of hair in front of the camera she added, "One brushing, this is my hair loss from Covid-19. Wear a d*** mask."